Impairment of Episodic and Working Memory as a Predictor of Dementia Development in Mild Cognitive Impairment Results From Four Years of Prospective Follow up
Abstract
Mild cognitive impairment (MCI) is a risk factor of dementia. Early impairment in episodic memory is considered to be a predictor of progression to dementia. The goal of the study was to evaluate the utility of baseline cognitive testing of episodic and working memory in the risk assessment of the dementia development in MCI. We studied 55 MCI patients and 44 controls, assessed annually by a set of neuropsychological tests for four years. The Petersen criteria were used to diagnose MCI, and DSM-IV criteria were applied to diagnose dementia. Variant analysis revealed significant differences in the results of individual cognitive tests between MCI converters who developed Alzheimer’s disease (AD) at follow up, MCI non-converters, and controls (p < 0,05). At baseline, MCI converters had significant impairment in all tests comparing to MCI non-converters. APOE4 status had a significant influence on AD development in our MCI group (p = 0,0022). The study showed that significant impairment in baseline results of tests evaluating episodic (delayed recall) and working memory in MCI is a good predictor of dementia development in the future.Key words: memory, mild cognitive impairment, dementia
References
Amieva H. et al.: Annual rate and predictors of conversion to dementia in subjects presenting mild cognitive impairment criteria defined according to a population‑based study. “Dementia and Geriatric Cognitive Disorders” 2004, No. 18, p. 87–93.
Baudic S. et al.: Executive function deficits in early Alzheimer’s disease and their relations with episodic memory. “Archives of Clinical Neuropsychology” 2006, No. 21, p. 15–21.
Beck A.T. et al.: An inventory for measuring depression. “Archives of General Psychiatry” 1961, No. 4, p. 53–63.
Belleville S. et al.: Characterizing the memory changes in persons with mild cognitive impairment. “Progress in Brain Research” 2008, No. 169, p. 365–375.
Caselli R.J. et al.: Cognitive domain decline in healthy apolipoprotein E ε4 homozygotes before the diagnosis of mild cognitive impairment. “Archives of Neurology” 2007, No. 64 (9), p. 1306–1311.
Daselaar S.M., Fleck M.S., Cabeza R.: Triple dissociation in the medial temporal lobes: recollection, familiarity, and novelty. “Journal of Neurophysiology” 2006, No. 96 (4), p. 1902–1911.
Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. Washington, American Psychiatric Association 1994.
Diana R.A., Yonelinas A.P., Ranganath C.: Imaging recollection and familiarity in the medial temporal lobe: a three‑component model. “Trends in Cognitive Sciences” 2007, No. 11 (9), p. 379–386.
Dubois B. et al.: Research criteria for the diagnosis of Alzheimer’s disease revising the NINDCS‑ADRDA criteria. “Lancet Neurology” 2007, No. 6 (8), p. 734–746.
Farlow M.R. et al.: Impact of APOE in mild cognitive impairment. “Neurology” 2004, No. 63, p. 1898–1901.
Foldi N.S.: Getting the hang of it: preferential gist over verbatim story recall and the roles of attentional capacity and the episodic buffer in Alzheimer disease. “Journal of the International Neuropsychological Society” 2011, No. 17 (1), p. 69–79.
Folstein M.F., Folstein S.E., McHugh P.R.: Mini‑mental state. A practical method for grading the cognitive state of patients for the clinician. “Journal of Psychiatric Research” 1975, No. 12, p. 189–198.
Gabryelewicz T. et al.: The rate of conversion of mild cognitive impairment to dementia: predictive role of depression. “International Journal of Geriatric Psychiatry” 2007, No. 22, p. 563–567.
Gatz J.L. et al.: Do depressive symptoms predict Alzheimer’s disease and dementia? “Journal of Gerontology” 2005, No. 60 (6), p. 744–747.
Hort J. et al.: EFNS guidelines for the diagnosis and management of Alzheimer’s disease. “European Journal of Neurology” 2010, No. 17, p. 1236–1248.
Huntley J.D., Howard R.J.: Working memory in early Alzheimer’s disease: a neuropsychological review. “International Journal of Geriatric Psychiatry” 2010, No. 25 (2), p. 121–132.
Lezak M.D., Howieson D.B., Loring D.W.: Neuropsychological Assessment. New York – Oxford, Oxford University Press 2004.
McKhann G. et al.: Clinical diagnosis of Alzheimer’s disease: report of NINCDS‑ADRDA Work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. “Neurology” 1984, No. 34, p. 939–944.
Montgomery S.A., Asberg M.: A new depression scale designed to be sensitive to change. “British Journal of Psychiatry” 1979, No. 134, p. 382–389.
Perri R. et al.: Amnestic mild cognitive impairment: difference of memory profile in subjects who converted or did not convert to Alzheimer’s disease. “Neuropsychology” 2007, No. 21 (5), p. 549–558.
Petersen R.C. et al.: Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory‑impaired individuals. “JAMA” 1995, No. 273 (16), p. 1274–1278.
Petersen R.C. et al.: Mild cognitive impairment: clinical characterization and outcome. “Archives of Neurology” 1999, No. 56, p. 303–308.
Petersen R.C. et al.: Prevalence of mild cognitive impairment is higher in men. “Neurology” 2010, No. 10, p. 889–897.
Price S.E. et al.: Learning and memory in amnestic mild cognitive impairment: contribution of working memory. “Journal of the International Neuropsychological Society” 2010, No. 16 (2), p. 342–351.
Redefining Alzheimer’s Disease: NIA and Alzheimer’s Association Float New Draft Diagnostic Criteria. (Alzheimer’s Association International Conference on Alzheimer’s Disease – ICAD, 2010). Honolulu 2010.
Roman G.C. et al.: Vascular dementia: diagnostic criteria for research studies. Report of the NINDS‑ARIEN International Workshop. “Neurology” 1993, No. 43, p. 250–260.
Rosenberg P.B., Johnston D., Lyketsos C.G.: A clinical approach to mild cognitive impairment. “American Journal of Psychiatry” 2006, No. 163 (11), p. 1884–1890.
Saiki R.K., Levenson C.H., Ehrlich H.A.: Genetic analysis of amplified DANN with immobilized sequence specific oligonucleotide probes. “Proceedings of the National Academy of Sciences” 1989, No. 86, p. 6230–6234.
Schulman K.L., Shedletsky R., Silver I.L.: The challenge of time: Clock drawing and cognitive function in the elderly. “International Journal of Geriatric Psychiatry” 1986, No. 1, p. 135–140.
Strauss E., Sherman E.M.S., Spreen O.: A Compendium of Neuropsychological Tests, Administration, Norms and Commentary. [Oxford ], Oxford University Press 2006.
Tabert M.H. et al.: Functional deficit in patients with mild cognitive impairment: prediction of AD. “Neurology” 2002, No. 58, p. 758–764.
Tervo S. et al.: Incidence and risk factors for mild cognitive impairment: A population‑based three‑year follow‑up study of cognitive healthy elderly subjects. “Dementia and Geriatric Cognitive Disorders” 2004, No. 17, p. 196–203.
Tognoni G. et al.: From mild cognitive impairment to dementia: a prevalence study in a district of Tuskany, Italy. “Acta Neurologica Scandinavica” 2005, No. 112, p. 65–71.
Unsworth N.: Variation in working memory capacity, fluid intelligence, and episodic recall: a latent variable examination of differences in the dynamics of free recall. “Memory & Cognition” 2009, No. 37 (6), p. 837–849.
Winblad B. et al.: Mild cognitive impairment: beyond controversies, towards a consensus. “Journal of Internal Medicine” 2004, No. 256, p. 240–246.
Wolf H. et al.: The prognosis of mild cognitive impairment in the elderly. “Journal of Neural Transmission” 1998, No. 54, p. 31–50.
Wolk D.A., Dickerson B.C.: Fractionating verbal episodic memory in Alzheimer’s disease. “Neuroimage” 2011, No. 54 (2), p. 1530–1539.
Yener G.G. et al.: Diagnosis profile and comparison of risk factors in major types of dementia: an hospital based study. “Journal of the Neurological Sciences” 2004, No. 21 (4), p. 301–310.
Katedra i Klinika Neurologii, Śląski Uniwersytet Medyczny w Katowicach Oddział Neurologii, Uniwersyteckie Centrum Kliniczne im. prof. Kornela Gibińskiego, Śląski Uniwersytet Medyczny w Katowicach
Oddział Neurologii, Uniwersyteckie Centrum Kliniczne im. prof. Kornela Gibińskiego, Śląski Uniwersytet Medyczny w Katowicach
Katedra i Klinika Neurologii, Śląski Uniwersytet Medyczny w Katowicach
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